Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | PI4KA | P42356 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL934788 | 1.00 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2CYP2C19CYP1A2 | |
| SCHEMBL17877912 | 0.87 | PIK3CD (0.39) | PIK3CDPIK3R1PIK3CGPIK3CBALDH1A1 | |
| SCHEMBL936036 | 0.83 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2CYP2C19CYP1A2 | |
| SCHEMBL30115073 | 0.78 | PIK3R1 (0.49) | NPC1RAB9ASMN1; SMN2CYP2C19CYP1A2 | |
| SCHEMBL1260644 | 0.78 | PIK3R1 (0.49) | NPC1RAB9ASMN1; SMN2CYP2C19CYP1A2 | |
| SCHEMBL17807064 | 0.78 | PIK3CD (0.35) | TSHRPIK3CDPIK3CGALDH1A1EPHB4 | |
| SCHEMBL936097 | 0.74 | PIK3R1 (0.42) | PIK3CDPIK3R1PIK3CGPIK3CB | |
| SCHEMBL934754 | 0.73 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2CYP2C19CYP1A2 | |
| SCHEMBL936140 | 0.73 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2CYP2C19CYP1A2 | |
| SCHEMBL28643134 | 0.73 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3613743-B1 | PROCESSES FOR THE PREPARATION OF 1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE DERIVATIVES | INTELLIKINE LLC (US) | 2022-03-16 | — | — | EP | disclosed |