Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 2/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 8/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GCG | P01275 | 2/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.31 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.31 |
| ▸ | CCNC | P24863 | 1/20 | 0.30 |
| ▸ | CDK8 | P49336 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29480703 | 0.80 | EGLN1 (0.39) | GRM4EGLN1GCGAURKAAURKB | |
| SCHEMBL22735741 | 0.80 | EGLN1 (0.39) | GRM4EGLN1GCGAURKAAURKB | |
| SCHEMBL22716885 | 0.79 | GCG (0.39) | EGLN1GCGJAK2 | |
| SCHEMBL29567469 | 0.79 | GCG (0.39) | EGLN1GCGJAK2 | |
| SCHEMBL22736280 | 0.77 | GRM4 (0.38) | GRM4EGLN1AURKAAURKBINCENP | |
| SCHEMBL29480555 | 0.77 | GRM4 (0.38) | GRM4EGLN1AURKAAURKBINCENP | |
| SCHEMBL22736532 | 0.77 | JAK2 (0.35) | EGLN1JAK2 | |
| SCHEMBL29480674 | 0.75 | JAK2 (0.41) | JAK2 | |
| SCHEMBL31158292 | 0.75 | GRM4 (0.58) | GRM4EGLN1AURKAAURKBINCENP | |
| SCHEMBL22736505 | 0.75 | GRM4 (0.58) | GRM4EGLN1AURKAAURKBINCENP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12516056-B2 | Compounds for inhibition of janus kinase 1 | MANKIND PHARMA LTD. (IN) | 2026-01-06 | — | — | US | claimed |
| CN-114174294-B | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2024-10-25 | — | — | CN | claimed |
| EP-3976612-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD (IN) | 2022-04-06 | — | — | EP | claimed |
| CN-114174294-A | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2022-03-11 | — | — | CN | claimed |