Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 7/20 | 0.34 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.32 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22736529 | 0.82 | PIK3CD (0.36) | JAK2JAK1JAK3KDM4EEGLN1 | |
| SCHEMBL29480520 | 0.81 | JAK1 (0.34) | JAK2JAK1JAK3EGLN1RET | |
| SCHEMBL22736015 | 0.81 | JAK1 (0.34) | JAK2JAK1JAK3EGLN1RET | |
| SCHEMBL22735747 | 0.80 | JAK2 (0.34) | JAK2JAK1JAK3CCNT1CDK9 | |
| SCHEMBL22716885 | 0.80 | GCG (0.39) | JAK2JAK3EGLN1 | |
| SCHEMBL29567469 | 0.80 | GCG (0.39) | JAK2JAK3EGLN1 | |
| SCHEMBL22735925 | 0.78 | PIK3CD (0.34) | KDM4EEGLN1CXCR4RIPK2RET | |
| SCHEMBL29480536 | 0.77 | GRM4 (0.35) | JAK2EGLN1 | |
| SCHEMBL22736279 | 0.76 | GRM5 (0.41) | JAK2JAK1JAK3KDM4EEGLN1 | |
| SCHEMBL29823952 | 0.76 | GRM5 (0.41) | JAK2JAK1JAK3KDM4EEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174294-B | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2024-10-25 | — | — | CN | disclosed |
| EP-3976612-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD (IN) | 2022-04-06 | — | — | EP | disclosed |
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |