Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 5/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.36 |
| ▸ | KDM4A | O75164 | 3/20 | 0.34 |
| ▸ | KDM4B | O94953 | 3/20 | 0.34 |
| ▸ | KDM5C | P41229 | 3/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.34 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.33 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29480532 | 0.79 | EGLN1 (0.41) | GRM4KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL22736505 | 0.77 | GRM4 (0.58) | GRM4KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL31158292 | 0.77 | GRM4 (0.58) | GRM4KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL29823952 | 0.77 | GRM5 (0.41) | GRM4KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL22736279 | 0.77 | GRM5 (0.41) | GRM4KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL22736159 | 0.74 | GRM4 (0.45) | GRM4HTR2BMTNR1AKCNH2 | |
| SCHEMBL22736083 | 0.73 | GRM4 (0.35) | GRM4GRM5AURKAAURKBINCENP | |
| SCHEMBL22736014 | 0.73 | GRM4 (0.38) | GRM4GRM5AURKAAURKBINCENP | |
| SCHEMBL22716872 | 0.73 | GRM4 (0.44) | GRM4GRM5HTR2BMTNR1AKCNH2 | |
| SCHEMBL29480627 | 0.73 | GRM4 (0.38) | GRM4GRM5AURKAAURKBINCENP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174294-A | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2022-03-11 | — | — | CN | claimed |
| CN-114174294-B | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2024-10-25 | — | — | CN | disclosed |
| CN-114174294-A | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2022-03-11 | — | — | CN | disclosed |