Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 3/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | GCG | P01275 | 3/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.30 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | GCGR | P47871 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29480507 | 0.93 | GCG (0.32) | GRM4JAK1GCGJAK2GCGR | |
| SCHEMBL29480456 | 0.86 | GCG (0.33) | GRM4JAK1GCGJAK2AURKA | |
| SCHEMBL29480524 | 0.85 | JAK2 (0.33) | GRM4JAK1JAK2 | |
| SCHEMBL22716901 | 0.83 | MAPK1 (0.33) | GRM4JAK2EGLN1AURKAAURKB | |
| SCHEMBL29568193 | 0.83 | MAPK1 (0.33) | GRM4JAK2EGLN1AURKAAURKB | |
| SCHEMBL22735745 | 0.83 | GRM4 (0.34) | GRM4GCGJAK2EGLN1AURKA | |
| SCHEMBL29567619 | 0.83 | GRM4 (0.34) | GRM4GCGJAK2EGLN1AURKA | |
| SCHEMBL29480518 | 0.82 | GRM4 (0.32) | GRM4JAK1GCGJAK2EGLN1 | |
| SCHEMBL29480486 | 0.82 | JAK2 (0.34) | GRM4JAK1GCGJAK2GCGR | |
| SCHEMBL29480579 | 0.82 | GRM4 (0.34) | GRM4GCGJAK2EGLN1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174294-A | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2022-03-11 | — | — | CN | claimed |
| CN-114174294-A | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2022-03-11 | — | — | CN | disclosed |