Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 3/20 | 0.41 |
| ▸ | MMP3 | P08254 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.38 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13174683 | 0.89 | POLB (0.52) | LMNAPOLBSMN1; SMN2THRBATM | |
| SCHEMBL7010085 | 0.84 | SMN1; SMN2 (0.54) | LMNAPOLBSMN1; SMN2MMP13MMP3 | |
| SCHEMBL4204342 | 0.84 | LMNA (0.54) | LMNAPOLBSMN1; SMN2MMP13MMP3 | |
| SCHEMBL13174685 | 0.84 | POLB (0.48) | LMNAPOLBSMN1; SMN2THRBATM | |
| SCHEMBL11974037 | 0.82 | POLB (0.58) | LMNAPOLBSMN1; SMN2THRBATM | |
| SCHEMBL725320 | 0.82 | LMNA (0.58) | LMNAPOLBSMN1; SMN2MMP13MMP3 | |
| SCHEMBL16256877 | 0.82 | LMNA (0.58) | LMNAPOLBSMN1; SMN2MMP13MMP3 | |
| SCHEMBL21379266 | 0.82 | HTT (0.39) | LMNAPOLBSMN1; SMN2THRBATM | |
| SCHEMBL6586204 | 0.81 | LMNA (0.54) | LMNAPOLBSMN1; SMN2MMP13MMP3 | |
| SCHEMBL726694 | 0.81 | SMN1; SMN2 (0.56) | LMNAPOLBSMN1; SMN2MMP13MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022165291-A1 | PHARMACEUTICAL COMPOSITIONS OF CGRP INHIBITORS AND METHODS OF THEIR USE | BIOHAVEN PHARMACEUTICAL HOLDING COMPANY LTD. (US) | 2022-08-04 | — | — | WO | disclosed |
| EP-3966215-A1 | SYNTHESIS OF LABELED IMIDAZO[1,2-A]PYRIMIDINES | F. Hoffmann-La Roche AG (CH) | 2022-03-16 | — | — | EP | disclosed |