Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.41 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.41 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4193447 | 0.86 | LMNA (0.51) | LMNAPOLBSMN1; SMN2GAATPSAB1 | |
| SCHEMBL7010085 | 0.85 | SMN1; SMN2 (0.54) | LMNAPOLBSMN1; SMN2GAATPSAB1 | |
| SCHEMBL13174683 | 0.84 | POLB (0.52) | LMNAPOLBSMN1; SMN2GAAATM | |
| SCHEMBL29480884 | 0.84 | LMNA (0.52) | LMNAPOLBSMN1; SMN2GAATPSAB1 | |
| SCHEMBL29480883 | 0.84 | LMNA (0.52) | LMNAPOLBSMN1; SMN2GAATPSAB1 | |
| SCHEMBL4200215 | 0.83 | POLB (0.46) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL725320 | 0.83 | LMNA (0.58) | LMNAPOLBSMN1; SMN2GAAATM | |
| SCHEMBL16256877 | 0.83 | LMNA (0.58) | LMNAPOLBSMN1; SMN2GAATPSAB1 | |
| SCHEMBL11974037 | 0.83 | POLB (0.58) | LMNAPOLBSMN1; SMN2GAAATM | |
| SCHEMBL29924072 | 0.82 | LMNA (0.54) | LMNAPOLBSMN1; SMN2GAATPSAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029578-A1 | 2-CARBOCYCLOAMINO-4-IMIDAZ0LYLPYRIMIDINES AS AGENTS FOR THE INHBITION OF CELL PROLIFERATION | AstraZeneca AB (SE) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007138277-A1 | 2-CARBOCYCLOAMINO-4-IMIDAZ0LYLPYRIMIDINES AS AGENTS FOR THE INHBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2007-12-06 | — | — | WO | disclosed |