Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DTYMK | P23919 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 2/20 | 0.36 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19358789 | 1.00 | DTYMK (0.43) | DTYMKCHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL19358788 | 0.88 | SETD7 (0.37) | DTYMKCHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL16156345 | 0.88 | PLK1 (0.42) | CHRM2CHRM4CHRM1CHRM3L3MBTL1 | |
| SCHEMBL31579034 | 0.86 | CNR2 (0.44) | CHRM2CHRM4CHRM1CHRM3CNR2 | |
| SCHEMBL20847265 | 0.86 | CNR2 (0.36) | CHRM2CHRM4CHRM1CHRM3CNR2 | |
| SCHEMBL29480900 | 0.86 | CNR2 (0.36) | CHRM2CHRM4CHRM1CHRM3CNR2 | |
| SCHEMBL19358796 | 0.86 | CNR2 (0.36) | CHRM2CHRM4CHRM1CHRM3CNR2 | |
| SCHEMBL17596556 | 0.83 | GPR119 (0.40) | CNR2IRAK4NSD2CETPGPR119 | |
| SCHEMBL19358786 | 0.81 | P2RX7 (0.37) | LMNAGLAL3MBTL1 | |
| SCHEMBL17596606 | 0.80 | GPR119 (0.37) | CNR2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232020-A1 | TREATMENT OF HEMATOLOGICAL MALIGNANCIES WITH INHIBITORS OF MENIN | Kura Oncology, Inc. (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2022086986-A1 | TREATMENT OF HEMATOLOGICAL MALIGNANCIES WITH INHIBITORS OF MENIN | KURA ONCOLOGY, INC. (US) | 2022-04-28 | — | — | WO | disclosed |