Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.54 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13239851 | 1.00 | PTGS2 (0.54) | PTGS2PTGS1GABRA2GABRB2KDM4E | |
| SCHEMBL13239853 | 0.89 | PTGS2 (0.50) | PTGS2PTGS1GABRA2GABRB2KDM4E | |
| SCHEMBL13239846 | 0.89 | PTGS2 (0.50) | PTGS2PTGS1GABRA2GABRB2KDM4E | |
| SCHEMBL5514584 | 0.88 | PTGS2 (0.54) | PTGS2PTGS1GABRA2GABRB2PTPN11 | |
| SCHEMBL13239848 | 0.88 | PTGS2 (0.41) | PTGS2PTGS1 | |
| SCHEMBL13239845 | 0.87 | PTGS2 (0.41) | PTGS2PTGS1 | |
| SCHEMBL13239849 | 0.85 | PTGS2 (0.52) | PTGS2PTGS1KDM4E | |
| SCHEMBL13239856 | 0.82 | PTGS2 (0.44) | PTGS2PTGS1GABRA2GABRB2 | |
| SCHEMBL5424741 | 0.78 | PTGS2 (0.56) | PTGS2PTGS1GABRA2GABRB2KDM4E | |
| SCHEMBL13239855 | 0.77 | PTGS2 (0.41) | PTGS2PTGS1GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7750032-B2 | Compounds and compositions as PPAR modulators | IRM LLC (BM) | 2010-07-06 | — | — | US | disclosed |
| US-7750032-B2 | Compounds and compositions as PPAR modulators | IRM LLC (BM) | 2010-07-06 | — | — | US | disclosed |
| US-7750032-B2 | Compounds and compositions as PPAR modulators | IRM LLC (BM) | 2010-07-06 | — | — | US | disclosed |
| US-20090137591-A1 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | IRM LLC (BM) | 2009-05-28 | — | — | US | disclosed |
| US-20090137591-A1 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | IRM LLC (BM) | 2009-05-28 | — | — | US | disclosed |
| US-20090137591-A1 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | IRM LLC (BM) | 2009-05-28 | — | — | US | disclosed |
| EP-1843763-A2 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | IRM, LLC (BM) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006084176-A2 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | IRM LLC (BM) | 2006-08-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137591-A1 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | PPARG, PPARD, PPARA | PTGS2 669/4885PTGS1 343/4885GABRA2 611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.