Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.56 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.52 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CCKAR | P32238 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5514584 | 0.91 | PTGS2 (0.54) | PTGS2GABRA2GABRB2P2RX7PTGS1 | |
| Hydrochloric Acid SCHEMBL5434406 | 0.78 | PTGS2 (0.53) | PTGS2GABRA2GABRB2PTGS1MEN1 | |
| SCHEMBL13239851 | 0.78 | PTGS2 (0.54) | PTGS2GABRA2GABRB2PTGS1RAB9A | |
| SCHEMBL2948230 | 0.78 | PTGS2 (0.54) | PTGS2GABRA2GABRB2PTGS1RAB9A | |
| SCHEMBL13239853 | 0.77 | PTGS2 (0.50) | PTGS2GABRA2GABRB2PTGS1RAB9A | |
| SCHEMBL13239846 | 0.77 | PTGS2 (0.50) | PTGS2GABRA2GABRB2PTGS1RAB9A | |
| SCHEMBL14513797 | 0.76 | PTGS2 (0.52) | PTGS2GABRA2GABRB2 | |
| SCHEMBL5423567 | 0.75 | GABRA2 (0.67) | PTGS2GABRA2GABRB2PTGS1CCKAR | |
| SCHEMBL5427563 | 0.75 | GABRA2 (0.64) | PTGS2GABRA2GABRB2PTGS1MEN1 | |
| SCHEMBL5420011 | 0.75 | PTGS2 (0.57) | PTGS2GABRA2GABRB2PTGS1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070043084-A1 | 1,2-Diarylimidazoles useful as inhibitors of cox | ASTELLAS PHARMA INC. (JP) | 2007-02-22 | — | — | US | disclosed |
| EP-1620406-A2 | 1,2-DIARYLIMIDAZOLES USEFUL AS INHIBITORS OF COX | Astellas Pharma Inc. (JP) | 2006-02-01 | — | — | EP | disclosed |
| WO-2004099130-A2 | 1,2-DIARYLIMIDAZOLES USEFUL AS INHIBITORS OF COX | ASTELLAS PHARMA INC. (JP) | 2004-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043084-A1 | 1,2-Diarylimidazoles useful as inhibitors of cox | PTGS1, COX15, CYP2E1 | PTGS2 4/4885GABRA2 2148/4885GABRB2 1446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.