Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 6/20 | 0.56 |
| ▸ | MMP2 | P08253 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MMP14 | P50281 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2948163 | 0.96 | MMP13 (0.58) | MMP13MMP2RAB9AKDM4EALDH1A1 | |
| SCHEMBL2944272 | 0.87 | MMP13 (0.59) | MMP13MMP2RAB9AKDM4EALDH1A1 | |
| SCHEMBL2949503 | 0.85 | MMP13 (0.57) | MMP13MMP2RAB9AKDM4EALDH1A1 | |
| SCHEMBL2943709 | 0.85 | HRH3 (0.66) | MMP13MMP2RAB9AKDM4EALDH1A1 | |
| SCHEMBL2949966 | 0.84 | HRH3 (0.51) | KDM4EALDH1A1HPGDHSD17B10HRH3 | |
| SCHEMBL2951278 | 0.84 | MMP13 (0.56) | MMP13MMP2RAB9AKDM4EALDH1A1 | |
| SCHEMBL2951713 | 0.82 | HRH3 (0.58) | MMP13MMP2RAB9AKDM4EALDH1A1 | |
| SCHEMBL3537292 | 0.81 | HRH3 (0.57) | MMP13MMP2RAB9AKDM4EALDH1A1 | |
| SCHEMBL2950369 | 0.80 | HRH3 (0.53) | KDM4EALDH1A1HPGDHSD17B10HRH3 | |
| SCHEMBL2951373 | 0.80 | MMP13 (0.60) | MMP13MMP2RAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7754736-B2 | 5-aminoindole derivatives as H3 inverse agonists | HOFFMANN-LA ROCHE INC. (US) | 2010-07-13 | — | — | US | disclosed |
| EP-1841734-B1 | 5-AMINOINDOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-07-29 | — | — | EP | disclosed |
| US-20090069311-A1 | 5-AMINOINDOLE DERIVATIVES AS H3 INVERSE AGONISTS | NETTEKOVEN MATTHIAS HEINRICH | 2009-03-12 | — | — | US | disclosed |
| US-7456174-B2 | 5-aminoindole derivatives as H3 inverse agonists | HOFFMANN-LA ROCHE INC. (US) | 2008-11-25 | — | — | US | disclosed |
| EP-1841734-A2 | 5-AMINOINDOLE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006077024-A2 | 5-AMINOINDOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-07-27 | — | — | WO | disclosed |
| US-20060160855-A1 | 5-Aminoindole derivatives as H3 inverse agonists | HOFFMANN-LA ROCHE INC. | 2006-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069311-A1 | 5-AMINOINDOLE DERIVATIVES AS H3 INVERSE AGONISTS | HRH3, HTR5A, HRH4 | MMP13 4255/4885MMP2 4466/4885RAB9A 1854/4885 |
| US-20060160855-A1 | 5-Aminoindole derivatives as H3 inverse agonists | HRH3, HTR5A, HRH4 | MMP13 4255/4885MMP2 4466/4885RAB9A 1854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.