Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.37 |
| ▸ | BUB1 | O43683 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22597585 | 0.84 | GPR119 (0.50) | IRAK4GPR119EPHA2EPHB4BUB1 | |
| SCHEMBL29483709 | 0.84 | GPR119 (0.50) | IRAK4GPR119EPHA2EPHB4BUB1 | |
| SCHEMBL29483697 | 0.84 | GPR119 (0.50) | IRAK4GPR119EPHA2EPHB4BUB1 | |
| SCHEMBL22597531 | 0.84 | GPR119 (0.50) | IRAK4GPR119EPHA2EPHB4BUB1 | |
| SCHEMBL30624457 | 0.84 | GPR119 (0.41) | IRAK4GPR119KCNH2P2RY12 | |
| SCHEMBL22588613 | 0.84 | IRAK4 (0.44) | IRAK4PDK1 | |
| SCHEMBL22588650 | 0.84 | IRAK4 (0.44) | IRAK4PDK1 | |
| SCHEMBL29483721 | 0.79 | IRAK4 (0.39) | IRAK4LMNAPOLBSMN1; SMN2GPR119 | |
| SCHEMBL22588657 | 0.77 | HRH3 (0.45) | IRAK4EPHA2KDREPHB4 | |
| SCHEMBL23764633 | 0.73 | POLB (0.58) | LMNAPOLBSMN1; SMN2PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3959211-A1 | 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE COMPOUNDS | Bayer Aktiengesellschaft (DE) | 2022-03-02 | — | — | EP | disclosed |