Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14707071 | 1.00 | MEN1 (0.54) | MEN1KMT2ATP53CYP3A4CYP1A2 | |
| SCHEMBL14707083 | 0.87 | HTR2A (0.47) | MEN1KMT2ACYP3A4CYP1A2SLC22A1 | |
| SCHEMBL7167351 | 0.87 | HTR2A (0.47) | MEN1KMT2ACYP3A4CYP1A2SLC22A1 | |
| SCHEMBL14707008 | 0.87 | HTR2A (0.47) | MEN1KMT2ACYP3A4CYP1A2SLC22A1 | |
| SCHEMBL11681069 | 0.83 | SLC6A2 (0.46) | MEN1KMT2ATP53CYP3A4CYP1A2 | |
| SCHEMBL11678606 | 0.82 | MEN1 (0.51) | MEN1KMT2ATP53CYP3A4CYP1A2 | |
| SCHEMBL11680286 | 0.79 | DRD4 (0.54) | MEN1KMT2ATP53CYP3A4CYP1A2 | |
| SCHEMBL15981159 | 0.77 | DHFR (0.41) | TP53HTR1AADRA2ADRD2ADRA2C | |
| SCHEMBL4669145 | 0.75 | CYP3A4 (0.65) | MEN1KMT2ATP53CYP3A4CYP1A2 | |
| SCHEMBL6963908 | 0.74 | HTR2A (0.71) | MEN1KMT2ATP53CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976185-A1 | HECT E3 LIGASE INHIBITORS AND USES THEREOF | IFOM - Fondazione Istituto FIRC di Oncologia Molecolare (IT) | 2022-04-06 | — | — | EP | disclosed |