Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | DNM2 | P50570 | 6/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | PCTP | Q9UKL6 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29349616 | 1.00 | NPC1 (0.52) | NPC1RAB9ADNM2EPHX1EPHX2 | |
| SCHEMBL29486340 | 1.00 | NPC1 (0.52) | NPC1RAB9ADNM2EPHX1EPHX2 | |
| SCHEMBL29486342 | 1.00 | NPC1 (0.52) | NPC1RAB9ADNM2EPHX1EPHX2 | |
| SCHEMBL18053805 | 1.00 | NPC1 (0.52) | NPC1RAB9ADNM2EPHX1EPHX2 | |
| SCHEMBL23258193 | 0.97 | NPC1 (0.51) | NPC1RAB9ADNM2EPHX1EPHX2 | |
| SCHEMBL23753656 | 0.96 | NPC1 (0.48) | NPC1RAB9ADNM2EPHX1EPHX2 | |
| SCHEMBL23258347 | 0.94 | NPC1 (0.51) | NPC1RAB9ADNM2EPHX1EPHX2 | |
| SCHEMBL25858229 | 0.93 | DNM2 (0.45) | NPC1RAB9ADNM2KMT2AMEN1 | |
| SCHEMBL18038014 | 0.91 | L3MBTL1 (0.50) | NPC1RAB9ADNM2KMT2AMEN1 | |
| SCHEMBL18037995 | 0.91 | NPC1 (0.52) | NPC1RAB9AEPHX1EPHX2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4199929-A1 | COMBINATION THERAPIES WITH OLIG2 INHIBITORS | Curtana Pharmaceuticals, Inc. (US) | 2023-06-28 | — | — | EP | disclosed |
| WO-2022046650-A1 | COMBINATION THERAPIES WITH OLIG2 INHIBITORS | Curtana Pharmaceuticals, Inc. (US) | 2022-03-03 | — | — | WO | disclosed |