Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | VDR | P11473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26653376 | 1.00 | NPC1L1 (0.49) | NPC1L1USP2LMNAALDH1A1MAPT | |
| SCHEMBL26653373 | 1.00 | NPC1L1 (0.49) | NPC1L1USP2LMNAALDH1A1MAPT | |
| SCHEMBL24358440 | 0.90 | NPC1L1 (0.51) | NPC1L1USP2LMNAALDH1A1MAPT | |
| SCHEMBL26783736 | 0.90 | NPC1L1 (0.51) | NPC1L1USP2LMNAALDH1A1MAPT | |
| SCHEMBL26653694 | 0.90 | NPC1L1 (0.51) | NPC1L1USP2LMNAALDH1A1MAPT | |
| SCHEMBL26783733 | 0.90 | NPC1L1 (0.51) | NPC1L1USP2LMNAALDH1A1MAPT | |
| SCHEMBL8610396 | 0.89 | POLB (0.57) | NPC1L1USP2LMNAALDH1A1MAPT | |
| SCHEMBL29486942 | 0.89 | LMNA (0.63) | NPC1L1USP2LMNAALDH1A1MAPT | |
| SCHEMBL29486944 | 0.89 | LMNA (0.63) | NPC1L1USP2LMNAALDH1A1MAPT | |
| SCHEMBL11232557 | 0.89 | LMNA (0.63) | NPC1L1USP2LMNAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022083809-A1 | CHOLESTANE DERIVATIVES, PREPARATIONS CONTAINING THESE DERIVATIVES AND USE THEREOF | Univerzita Palackého v Olomouci (CZ) | 2022-04-28 | — | — | WO | disclosed |