SCHEMBL29487137

SCHEMBL29487137

Cn1cnc(-c2cc3nccc(Oc4ccc(N)cc4F)c3s2)c1

nearest known ligand 0.63

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MET P08581 19/20 0.63
KDR P35968 15/20 0.63
MST1R Q04912 9/20 0.57
AURKA O14965 1/20 0.56
FPR1 P21462 1/20 0.56
FPR3 P25089 1/20 0.56
GPR183 P32249 1/20 0.56
SMO Q99835 1/20 0.56
GPR35 Q9HC97 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL306299 1.00 MET (0.63) METKDRMST1RAURKAFPR1
SCHEMBL18516664 0.88 MET (0.64) METKDRMST1RAURKAFPR1
SCHEMBL306863 0.87 MET (0.57) METKDR
SCHEMBL307719 0.87 MET (0.57) METKDRMST1R
SCHEMBL307222 0.87 MET (0.66) METKDRMST1R
SCHEMBL13253651 0.86 MET (0.63) METKDRMST1RAURKAFPR1
SCHEMBL18516323 0.86 MET (0.71) METKDRMST1RAURKAFPR1
SCHEMBL307217 0.86 MET (0.54) METKDR
SCHEMBL308540 0.85 MET (0.55) METKDR
SCHEMBL306019 0.85 MET (0.61) METKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114206883-A Oxopyridine fused ring derivative and pharmaceutical composition comprising the same 伟迈可生物有限公司 2022-03-18 CN disclosed