SCHEMBL29487560

SCHEMBL29487560

Fc1cccc([C@H]2CC[C@@H](OCc3ncccc3Br)CC2)c1

nearest known ligand 0.40

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
HCRTR2 O43614 16/20 0.40
HDAC4 P56524 1/20 0.37
MLYCD O95822 1/20 0.35
DRD4 P21917 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23293095 1.00 HCRTR2 (0.40) HCRTR2HDAC4MLYCDDRD4
SCHEMBL23293093 1.00 HCRTR2 (0.40) HCRTR2HDAC4MLYCDDRD4
SCHEMBL28675350 0.91 HCRTR2 (0.35) HCRTR2DRD4
SCHEMBL29487583 0.91 HCRTR2 (0.35) HCRTR2DRD4
SCHEMBL23293091 0.87 HCRTR2 (0.41) HCRTR2HDAC4MLYCDDRD4
SCHEMBL23293090 0.87 HCRTR2 (0.41) HCRTR2HDAC4MLYCDDRD4
SCHEMBL22969642 0.85 NR3C1 (0.38) HCRTR2
SCHEMBL24497826 0.85 NR3C1 (0.38) HCRTR2
SCHEMBL23922914 0.85 NR3C1 (0.38) HCRTR2
SCHEMBL29487590 0.85 NR3C1 (0.38) HCRTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114181136-A Substituted piperidine compounds and uses thereof 武田药品工业株式会社 2022-03-15 CN disclosed