Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PSIP1 | O75475 | 2/20 | 0.42 |
| ▸ | FLT4 | P35916 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28676474 | 1.00 | KMT2A (0.45) | KMT2AGAAPSIP1FLT4KDR | |
| SCHEMBL15531384 | 0.84 | NAMPT (0.51) | PSIP1FLT4KDRPLK4AURKA | |
| SCHEMBL1403612 | 0.84 | KDM4E (0.50) | KMT2APSIP1ALDH1A1KDM4E | |
| SCHEMBL17168943 | 0.84 | ALDH1A1 (0.40) | KMT2AGAAPSIP1KIF11ALDH1A1 | |
| SCHEMBL10516843 | 0.83 | MAPT (0.41) | KMT2AGAAPSIP1KIF11ALDH1A1 | |
| SCHEMBL29488691 | 0.82 | KMT2A (0.47) | KMT2AFLT4KDRAURKAROCK2 | |
| SCHEMBL2697225 | 0.82 | KMT2A (0.47) | KMT2AFLT4KDRAURKAROCK2 | |
| SCHEMBL18248737 | 0.80 | RORC (0.46) | GAAPSIP1FLT4KDRPLK4 | |
| SCHEMBL3449352 | 0.79 | KMT2A (0.47) | KMT2AGSK3BSIRT6ALDH1A1KDM4E | |
| SCHEMBL15530424 | 0.77 | NAMPT (0.44) | KMT2ANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114230523-A | Benzimidazole derivatives as modulators of ROR-gamma | 生命医药有限责任公司 | 2022-03-25 | — | — | CN | disclosed |