Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.42 |
| ▸ | CTPS1 | P17812 | 10/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24369606 | 1.00 | RAB9A (0.44) | RAB9ANPC1KMT2ACASP3SENP8 | |
| SCHEMBL29488966 | 0.85 | CTPS1 (0.43) | CTPS1 | |
| SCHEMBL24369400 | 0.85 | CTPS1 (0.43) | CTPS1 | |
| SCHEMBL29488837 | 0.84 | CTPS1 (0.44) | RAB9ANPC1KMT2ACTPS1MEN1 | |
| SCHEMBL24369378 | 0.84 | CTPS1 (0.44) | RAB9ANPC1KMT2ACTPS1MEN1 | |
| SCHEMBL24369711 | 0.83 | CTPS1 (0.42) | CTPS1 | |
| SCHEMBL29488880 | 0.83 | CTPS1 (0.42) | CTPS1 | |
| SCHEMBL24369028 | 0.82 | CTPS1 (0.45) | CTPS1 | |
| SCHEMBL29488835 | 0.82 | CTPS1 (0.45) | CTPS1 | |
| SCHEMBL24369605 | 0.82 | RAB9A (0.46) | RAB9ANPC1KMT2ACASP3SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232425-A1 | CTPS1 INHIBITORS AND USES THEREOF | Nimbus Clotho, Inc. (US) | 2023-08-30 | — | — | EP | disclosed |
| CN-116601131-A | CTPS1 inhibitor and application thereof | 林伯士克洛索有限公司 | 2023-08-15 | — | — | CN | disclosed |
| WO-2022087634-A1 | CTPS1 INHIBITORS AND USES THEREOF | NIMBUS CLOTHO, INC. (US) | 2022-04-28 | — | — | WO | disclosed |