Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTPS1 | P17812 | 11/20 | 0.42 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | CTPS2 | Q9NRF8 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24369711 | 1.00 | CTPS1 (0.42) | CTPS1BCAT1HPGDSCXCR4MGAM | |
| SCHEMBL24369162 | 0.88 | CTPS1 (0.45) | CTPS1BCAT1CTPS2 | |
| SCHEMBL29488826 | 0.88 | CTPS1 (0.45) | CTPS1BCAT1CTPS2 | |
| SCHEMBL29488837 | 0.87 | CTPS1 (0.44) | CTPS1CTPS2 | |
| SCHEMBL24369378 | 0.87 | CTPS1 (0.44) | CTPS1CTPS2 | |
| SCHEMBL24370239 | 0.83 | HPGDS (0.42) | BCAT1HPGDSCXCR4MGAMDPP4 | |
| SCHEMBL29488966 | 0.83 | CTPS1 (0.43) | CTPS1CTPS2 | |
| SCHEMBL24369400 | 0.83 | CTPS1 (0.43) | CTPS1CTPS2 | |
| SCHEMBL24369606 | 0.83 | RAB9A (0.44) | CTPS1 | |
| SCHEMBL29488891 | 0.83 | RAB9A (0.44) | CTPS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232425-A1 | CTPS1 INHIBITORS AND USES THEREOF | Nimbus Clotho, Inc. (US) | 2023-08-30 | — | — | EP | disclosed |
| CN-116601131-A | CTPS1 inhibitor and application thereof | 林伯士克洛索有限公司 | 2023-08-15 | — | — | CN | disclosed |
| WO-2022087634-A1 | CTPS1 INHIBITORS AND USES THEREOF | NIMBUS CLOTHO, INC. (US) | 2022-04-28 | — | — | WO | disclosed |