Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL856384 | 1.00 | MPO (0.43) | MPOACHEPKMKMT2ARXFP1 | |
| SCHEMBL30014038 | 0.81 | ACHE (0.42) | MPOACHEKMT2AMEN1MAPT | |
| SCHEMBL1994310 | 0.81 | ACHE (0.42) | MPOACHEKMT2AMEN1MAPT | |
| SCHEMBL14970172 | 0.81 | MPO (0.57) | MPOACHEPKMKMT2AMEN1 | |
| SCHEMBL31391615 | 0.78 | MPO (0.43) | MPOACHEPKMKMT2AAURKA | |
| SCHEMBL5402128 | 0.78 | MPO (0.43) | MPOACHERXFP1PDE10APOLB | |
| SCHEMBL29767527 | 0.78 | MPO (0.46) | MPOACHEPDE10AMAPTABL1 | |
| SCHEMBL12481107 | 0.78 | ACHE (0.42) | MPOACHEKMT2ARXFP1MAPT | |
| SCHEMBL30294150 | 0.78 | MPO (0.46) | MPOACHEPKMKMT2AAURKA | |
| SCHEMBL2777857 | 0.78 | MPO (0.46) | MPOACHEPDE10AMAPTABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4329755-A1 | EXPANDED DOSAGE REGIMENS FOR INTEGRIN INHIBITORS | Pliant Therapeutics, Inc. (US) | 2024-03-06 | — | — | EP | disclosed |
| WO-2022232838-A1 | EXPANDED DOSAGE REGIMENS FOR INTEGRIN INHIBITORS | PLIANT THERAPEUTICS, INC. (US) | 2022-11-03 | — | — | WO | disclosed |
| EP-3976009-A2 | BAX INHIBITORS AND USES THEREOF | Case Western Reserve University (US) | 2022-04-06 | — | — | EP | disclosed |