Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 2/20 | 0.47 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22862695 | 1.00 | TSHR (0.59) | TSHRMAPTHPGDPOLBTP53 | |
| SCHEMBL5837254 | 0.82 | SMN1; SMN2 (0.53) | TSHRMAPTHPGDPOLBTP53 | |
| SCHEMBL22862697 | 0.82 | ALDH1A1 (0.65) | TSHRMAPTHPGDPOLBTP53 | |
| SCHEMBL22862586 | 0.80 | SMN1; SMN2 (0.50) | TSHRPOLBTP53RAB9ASMN1; SMN2 | |
| SCHEMBL22493184 | 0.77 | TSHR (0.54) | TSHRMAPTHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL15270384 | 0.77 | HPGD (0.54) | TSHRMAPTHPGDTP53THRB | |
| SCHEMBL25719557 | 0.76 | TSHR (0.53) | TSHRMAPTHPGDPOLBTHRB | |
| SCHEMBL14825105 | 0.75 | HPGD (1.00) | TSHRMAPTHPGDPOLBRAB9A | |
| SCHEMBL2183508 | 0.75 | HPGD (0.84) | TSHRMAPTHPGDPOLBALDH1A1 | |
| SCHEMBL29490252 | 0.74 | POLB (0.54) | TSHRPOLBTP53THRBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976009-A2 | BAX INHIBITORS AND USES THEREOF | Case Western Reserve University (US) | 2022-04-06 | — | — | EP | disclosed |