Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29490184 | 0.90 | NPC1 (0.51) | NPC1RAB9ALMNATRPV1POLB | |
| SCHEMBL27482373 | 0.78 | HCRTR1 (0.46) | NPC1RAB9AHRH3KMT2APOLB | |
| SCHEMBL24233562 | 0.75 | HTR2B (0.49) | HTR2BHRH3 | |
| SCHEMBL19824770 | 0.74 | NPC1 (0.65) | NPC1RAB9ALMNATRPV1KMT2A | |
| SCHEMBL24427996 | 0.73 | MAPKAPK2 (0.48) | NPC1RAB9AHRH3KMT2APOLB | |
| SCHEMBL482663 | 0.73 | ALDH1A1 (0.44) | NPC1RAB9ALMNAKMT2AMAPT | |
| SCHEMBL11364480 | 0.71 | HTR2B (0.43) | NPC1RAB9AHTR2BPOLBMAPT | |
| SCHEMBL27526929 | 0.70 | NPY5R (0.50) | NPC1RAB9AHTR2BLMNAPKM | |
| SCHEMBL5772605 | 0.69 | CYP2D6 (0.52) | NPC1RAB9AHTR2BMAPTHSD17B10 | |
| SCHEMBL24726102 | 0.69 | CTNNB1 (0.53) | NPC1RAB9AKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976009-A2 | BAX INHIBITORS AND USES THEREOF | Case Western Reserve University (US) | 2022-04-06 | — | — | EP | disclosed |