Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sivelestat. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE known ✓ | P08246 | 16/20 | 0.68 |
| ▸ | PRTN3 | P24158 | 12/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sivelestat SCHEMBL7107254 | 1.00 | ELANE (0.68) | ELANEPRTN3KDM4EGAAHSD17B10 | |
| Sivelestat SCHEMBL29677633 | 0.99 | ELANE (0.69) | ELANEPRTN3KDM4EGAAHSD17B10 | |
| Sivelestat SCHEMBL4411778 | 0.99 | ELANE (0.69) | ELANEPRTN3KDM4EGAAHSD17B10 | |
| Sivelestat SCHEMBL6690886 | 0.91 | ELANE (0.69) | ELANEPRTN3KDM4EGAAHSD17B10 | |
| Sivelestat SCHEMBL30864380 | 0.91 | ELANE (0.69) | ELANEPRTN3KDM4EGAAHSD17B10 | |
| Sivelestat SCHEMBL597819 | 0.90 | ELANE (0.68) | ELANEPRTN3KDM4EGAAHSD17B10 | |
| Sivelestat SCHEMBL1499929 | 0.90 | ELANE (0.68) | ELANEPRTN3KDM4EGAAHSD17B10 | |
| Sivelestat SCHEMBL4411781 | 0.90 | ELANE (0.71) | ELANEPRTN3KDM4EGAAHSD17B10 | |
| SCHEMBL7267891 | 0.90 | ELANE (0.71) | ELANEPRTN3KDM4EGAAHSD17B10 | |
| Sivelestat SCHEMBL123221 | 0.90 | ELANE (0.71) | ELANEPRTN3KDM4EGAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4744663-A2 | SKIN COMPOSITION | Eaderm Co., Ltd. (JP) | 2026-05-20 | — | — | EP | disclosed |
| EP-4205750-B1 | NADPH OXIDASE INHIBITOR FOR SUPPRESSING OR IMPROVING HAIR LOSS OR TREATING ALOPECIA | EADERM CO LTD (JP) | 2025-04-09 | — | — | EP | disclosed |
| WO-2025049724-A1 | COMPOSITIONS AND METHODS FOR TREATING PLEURAL SPACE INFECTIONS AND HEMOTHORAX | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2025-03-06 | — | — | WO | disclosed |
| WO-2024254398-A2 | MODULATION OF NEUTROPHIL ACTIVATION AND NEUTROPHIL EXTRACELLULAR TRAP (NET) FORMATION | REDD PHARMACEUTICALS, INC. (US) | 2024-12-12 | — | — | WO | disclosed |
| WO-2024192873-A1 | USE OF SMALL MOLECULE COMPOUND HAVING NAPHTHYLAMINE STRUCTURE | 杭州天玑济世生物科技有限公司 | 2024-09-26 | — | — | WO | disclosed |
| WO-2024193529-A1 | USE OF SMALL-MOLECULE COMPOUND HAVING NAPHTHYLAMINE STRUCTURE | 杭州天玑济世生物科技有限公司 | 2024-09-26 | — | — | WO | disclosed |
| CN-117982414-B | Sivelesta sodium nanocrystalline, dry powder and inhalation powder fog agent thereof and preparation method thereof | 暨南大学 | 2024-07-02 | — | — | CN | disclosed |
| US-20240207484-A1 | CARTILAGE TREATMENT FOR USE IN EYELID RECONSTRUCTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-06-27 | — | — | US | disclosed |
| CN-118079006-A | Skin composition | 国立大学法人东京医科齿科大学 | 2024-05-28 | — | — | CN | disclosed |
| CN-117982414-A | Sivelesta sodium nanocrystalline, dry powder and inhalation powder fog agent thereof and preparation method thereof | 暨南大学 | 2024-05-07 | — | — | CN | disclosed |
| US-20240099295-A1 | CELL TREATMENT AGENT | AYA INC. (JP) | 2024-03-28 | — | — | US | disclosed |
| WO-2024008131-A1 | NEW USE OF SIVELESTAT | 上海汇伦医药股份有限公司 | 2024-01-11 | — | — | WO | disclosed |
| EP-3403673-B1 | COMPOSITION FOR PREVENTING OR AMELIORATING LOSS OF HAIR AND GRAYING OF HAIR, AND USE THEREOF | UNIV NAT CORP TOKYO MEDICAL & DENTAL (JP) | 2023-10-11 | — | — | EP | disclosed |
| US-20230288403-A1 | METHOD FOR INDUCING EXTRACELLULAR TRAP (ET) FORMATION | Tridek-One Therapeutics (FR) | 2023-09-14 | — | — | US | disclosed |
| EP-4227684-A1 | METHOD FOR INDUCING NEUTROPHIL EXTRACELLULAR TRAP (NET) FORMATION | Tridek-One Therapeutics (FR) | 2023-08-16 | — | — | EP | disclosed |
| EP-4205750-A1 | COMPOSITIONS FOR SUPPRESSING OR IMPROVING HAIR LOSS AND GRAYING, AND USES THEREOF | National University Corporation Tokyo Medical and Dental University (JP) | 2023-07-05 | — | — | EP | disclosed |
| WO-2022232516-A1 | CARTILAGE TREATMENT FOR USE IN EYELID RECONSTRUCTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-11-03 | — | — | WO | disclosed |
| US-20220331389-A1 | SKIN COMPOSITION | EADERM CO., LTD. (JP) | 2022-10-20 | — | — | US | disclosed |
| US-11298372-B2 | Composition for ameliorating loss of hair and graying of hair, and use thereof | NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY (JP) | 2022-04-12 | — | — | US | disclosed |
| EP-3978020-A1 | SKIN COMPOSITION | National University Corporation Tokyo Medical and Dental University (JP) | 2022-04-06 | — | — | EP | disclosed |