Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sivelestat. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE known ✓ | P08246 | 16/20 | 0.68 |
| ▸ | PRTN3 | P24158 | 12/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sivelestat SCHEMBL597819 | 1.00 | ELANE (0.68) | ELANEPRTN3NPC1RAB9AKDM4E | |
| Sivelestat SCHEMBL566914 | 0.99 | ELANE (0.69) | ELANEPRTN3NPC1RAB9AKDM4E | |
| Sivelestat SCHEMBL6690886 | 0.99 | ELANE (0.69) | ELANEPRTN3NPC1RAB9AKDM4E | |
| Sivelestat SCHEMBL30864380 | 0.99 | ELANE (0.69) | ELANEPRTN3NPC1RAB9AKDM4E | |
| Sivelestat SCHEMBL28751433 | 0.98 | ELANE (0.71) | ELANEPRTN3NPC1RAB9AKDM4E | |
| Sivelestat SCHEMBL4411781 | 0.98 | ELANE (0.71) | ELANEPRTN3NPC1RAB9AKDM4E | |
| Sivelestat SCHEMBL123221 | 0.98 | ELANE (0.71) | ELANEPRTN3NPC1RAB9AKDM4E | |
| Sivelestat SCHEMBL29490347 | 0.90 | ELANE (0.68) | ELANEPRTN3NPC1KDM4EGAA | |
| Sivelestat SCHEMBL7107254 | 0.90 | ELANE (0.68) | ELANEPRTN3NPC1KDM4EGAA | |
| SCHEMBL7267891 | 0.90 | ELANE (0.71) | ELANEPRTN3KDM4EGAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12134796-B2 | Methods of prediction of wound healing | WOUNDCHEK LABORATORIES (US), INC. (US) | 2024-11-05 | — | — | US | claimed |
| EP-3353316-B1 | METHODS OF PREDICTION OF WOUND HEALING | WOUNDCHEK LABORATORIES INC (US) | 2024-01-10 | — | — | EP | claimed |
| CN-113874044-A | Skin composition | 国立大学法人东京医科齿科大学 | 2021-12-31 | — | — | CN | claimed |
| US-20200392557-A1 | METHODS OF PREDICTION OF WOUND HEALING | WOUNDCHEK LABORATORIES (US), INC. (US) | 2020-12-17 | — | — | US | claimed |
| US-20180346959-A1 | Methods of Prediction of Wound Healing | WOUNDCHEK LABORATORIES (US), INC. | 2018-12-06 | — | — | US | claimed |
| EP-3353316-A1 | METHODS OF PREDICTION OF WOUND HEALING | Woundchek Laboratories, Inc. (US) | 2018-08-01 | — | — | EP | claimed |
| WO-2017053931-A1 | METHODS OF PREDICTION OF WOUND HEALING | WoundChek Laboratories, Inc. (US) | 2017-03-30 | — | — | WO | claimed |
| CN-101575306-B | Method for preparing sivelestat sodium | SHANGHAI YOUSHOU MEDICAL TECHNOLOGY DEV CO LTD | 2012-11-21 | — | — | CN | claimed |
| CN-101575306-A | Method for preparing sivelestat sodium | SHANGHAI YOUSHOU MEDICAL TECHN (CN) | 2009-11-11 | — | — | CN | claimed |
| US-12134796-B2 | Methods of prediction of wound healing | WOUNDCHEK LABORATORIES (US), INC. (US) | 2024-11-05 | — | — | US | disclosed |
| CN-118079006-A | Skin composition | 国立大学法人东京医科齿科大学 | 2024-05-28 | — | — | CN | disclosed |
| CN-113874044-B | Skin composition | 国立大学法人东京医科齿科大学 | 2024-03-29 | — | — | CN | disclosed |
| US-20240082203-A1 | PHARMACEUTICAL COMPOSITION FOR INHALATION | Shanghai Huilun Pharmaceutical Co., Ltd. (CN) | 2024-03-14 | — | — | US | disclosed |
| EP-3353316-B1 | METHODS OF PREDICTION OF WOUND HEALING | WOUNDCHEK LABORATORIES INC (US) | 2024-01-10 | — | — | EP | disclosed |
| CN-101575306-B | Method for preparing sivelestat sodium | SHANGHAI YOUSHOU MEDICAL TECHNOLOGY DEV CO LTD | 2012-11-21 | — | — | CN | disclosed |
| CN-102438990-A | Substituted 2-acetamido-5-aryl-1, 2, 4-triazolones and use thereof | BAYER SCHERING PHARMA AG | 2012-05-02 | — | — | CN | disclosed |
| JP-2011051974-A | METHOD FOR SYNTHESIZING SIVELESTAT | PROCOS SPA | 2011-03-17 | — | — | JP | disclosed |
| CN-101575306-A | Method for preparing sivelestat sodium | SHANGHAI YOUSHOU MEDICAL TECHN (CN) | 2009-11-11 | — | — | CN | disclosed |
| CN-1241936-C | Polypeptide of inhibiting crown virus and its derivant | UNIV TIANJIN (CN) | 2006-02-15 | — | — | CN | disclosed |
| CN-1560074-A | Polypeptide of inhibiting crown virus and its derivant | 天津师范大学 | 2005-01-05 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240082203-A1 | PHARMACEUTICAL COMPOSITION FOR INHALATION | AQP1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, AQP4 | ELANE 3681/4885PRTN3 3578/4885NPC1 316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.