Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sivelestat. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE known ✓ | P08246 | 16/20 | 0.69 |
| ▸ | PRTN3 | P24158 | 12/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sivelestat SCHEMBL6690886 | 1.00 | ELANE (0.69) | ELANEPRTN3NPC1RAB9AKDM4E | |
| Sivelestat SCHEMBL1499929 | 0.99 | ELANE (0.68) | ELANEPRTN3NPC1RAB9AKDM4E | |
| Sivelestat SCHEMBL597819 | 0.99 | ELANE (0.68) | ELANEPRTN3NPC1RAB9AKDM4E | |
| Sivelestat SCHEMBL28751433 | 0.99 | ELANE (0.71) | ELANEPRTN3NPC1RAB9AKDM4E | |
| Sivelestat SCHEMBL4411781 | 0.99 | ELANE (0.71) | ELANEPRTN3NPC1RAB9AKDM4E | |
| Sivelestat SCHEMBL123221 | 0.99 | ELANE (0.71) | ELANEPRTN3NPC1RAB9AKDM4E | |
| Sivelestat SCHEMBL566914 | 0.98 | ELANE (0.69) | ELANEPRTN3NPC1RAB9AKDM4E | |
| Sivelestat SCHEMBL29490347 | 0.91 | ELANE (0.68) | ELANEPRTN3NPC1KDM4EGAA | |
| Sivelestat SCHEMBL7107254 | 0.91 | ELANE (0.68) | ELANEPRTN3NPC1KDM4EGAA | |
| SCHEMBL7267891 | 0.91 | ELANE (0.71) | ELANEPRTN3KDM4EGAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118079006-A | Skin composition | 国立大学法人东京医科齿科大学 | 2024-05-28 | — | — | CN | disclosed |
| CN-113874044-B | Skin composition | 国立大学法人东京医科齿科大学 | 2024-03-29 | — | — | CN | disclosed |