Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 1/20 | 0.52 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 8/20 | 0.49 |
| ▸ | JAK1 | P23458 | 6/20 | 0.49 |
| ▸ | JAK2 | O60674 | 5/20 | 0.49 |
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.48 |
| ▸ | FLT4 | P35916 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | ROS1 | P08922 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22635157 | 1.00 | ULK1 (0.52) | ULK1ULK2JAK3JAK1JAK2 | |
| SCHEMBL29490507 | 0.90 | JAK3 (0.49) | ULK1ULK2JAK3JAK1JAK2 | |
| SCHEMBL22635291 | 0.90 | JAK3 (0.49) | ULK1ULK2JAK3JAK1JAK2 | |
| SCHEMBL22635205 | 0.90 | FLT4 (0.48) | JAK3JAK1JAK2TBK1FLT4 | |
| SCHEMBL29490427 | 0.90 | FLT4 (0.48) | JAK3JAK1JAK2TBK1FLT4 | |
| SCHEMBL22635441 | 0.90 | TBK1 (0.46) | ULK1ULK2JAK3JAK1JAK2 | |
| SCHEMBL29490560 | 0.90 | TBK1 (0.46) | ULK1ULK2JAK3JAK1JAK2 | |
| SCHEMBL22635138 | 0.90 | TBK1 (0.60) | ULK1ULK2JAK3JAK1JAK2 | |
| SCHEMBL22635455 | 0.90 | JAK1 (0.51) | ULK1ULK2JAK3JAK1JAK2 | |
| SCHEMBL29490543 | 0.90 | JAK1 (0.51) | ULK1ULK2JAK3JAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3966206-B1 | HETEROARYLAMINOPYRIMIDINE AMIDE AUTOPHAGY INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS LLC (US) | 2023-08-09 | — | — | EP | claimed |
| EP-3966206-A1 | HETEROARYLAMINOPYRIMIDINE AMIDE AUTOPHAGY INHIBITORS AND METHODS OF USE THEREOF | Deciphera Pharmaceuticals, LLC (US) | 2022-03-16 | — | — | EP | claimed |
| EP-3966206-A1 | HETEROARYLAMINOPYRIMIDINE AMIDE AUTOPHAGY INHIBITORS AND METHODS OF USE THEREOF | Deciphera Pharmaceuticals, LLC (US) | 2022-03-16 | — | — | EP | disclosed |