Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.48 |
| ▸ | JAK1 | P23458 | 8/20 | 0.48 |
| ▸ | JAK3 | P52333 | 8/20 | 0.48 |
| ▸ | JAK2 | O60674 | 6/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22635074 | 1.00 | TBK1 (0.48) | TBK1JAK1JAK3JAK2CDK4 | |
| SCHEMBL29490543 | 0.91 | JAK1 (0.51) | TBK1JAK1JAK3JAK2TYK2 | |
| SCHEMBL22635455 | 0.91 | JAK1 (0.51) | TBK1JAK1JAK3JAK2TYK2 | |
| SCHEMBL22635441 | 0.89 | TBK1 (0.46) | TBK1JAK1JAK3JAK2TYK2 | |
| SCHEMBL29490560 | 0.89 | TBK1 (0.46) | TBK1JAK1JAK3JAK2TYK2 | |
| SCHEMBL22635241 | 0.89 | TBK1 (0.48) | TBK1JAK1JAK3JAK2CDK4 | |
| SCHEMBL29490538 | 0.89 | TBK1 (0.48) | TBK1JAK1JAK3JAK2CDK4 | |
| SCHEMBL22635196 | 0.89 | TBK1 (0.46) | TBK1JAK1JAK3JAK2CDK4 | |
| SCHEMBL29490445 | 0.89 | TBK1 (0.46) | TBK1JAK1JAK3JAK2CDK4 | |
| SCHEMBL22635617 | 0.89 | ULK1 (0.52) | TBK1JAK1JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3966206-A1 | HETEROARYLAMINOPYRIMIDINE AMIDE AUTOPHAGY INHIBITORS AND METHODS OF USE THEREOF | Deciphera Pharmaceuticals, LLC (US) | 2022-03-16 | — | — | EP | claimed |
| EP-4295846-A2 | HETEROARYLAMINOPYRIMIDINE AMIDE AUTOPHAGY INHIBITORS AND METHODS OF USE THEREOF | Deciphera Pharmaceuticals, LLC (US) | 2023-12-27 | — | — | EP | disclosed |
| EP-3966206-A1 | HETEROARYLAMINOPYRIMIDINE AMIDE AUTOPHAGY INHIBITORS AND METHODS OF USE THEREOF | Deciphera Pharmaceuticals, LLC (US) | 2022-03-16 | — | — | EP | disclosed |