Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 4/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27773575 | 0.82 | KMT2A (0.46) | KMT2ADRD2DRD4DRD3LRRK2 | |
| SCHEMBL15034177 | 0.82 | — | — | |
| SCHEMBL17001832 | 0.81 | GAA (0.41) | DRD2DRD4DRD3HTR2AHRH1 | |
| SCHEMBL22781479 | 0.80 | SIGMAR1 (0.44) | DRD2HTR2AHRH1HRH3SIGMAR1 | |
| SCHEMBL10049903 | 0.78 | SIGMAR1 (0.39) | TP53ALDH1A1SIGMAR1 | |
| SCHEMBL16969326 | 0.78 | SIGMAR1 (0.36) | TP53ALDH1A1SIGMAR1 | |
| SCHEMBL27364240 | 0.78 | DRD2 (0.36) | DRD2DRD4DRD3HTR2AHRH1 | |
| SCHEMBL27367010 | 0.78 | CACNA2D1 (0.38) | DRD2DRD4DRD3HTR2AHRH1 | |
| SCHEMBL10049902 | 0.77 | SIGMAR1 (0.41) | KMT2ATP53ALDH1A1SIGMAR1 | |
| SCHEMBL15448695 | 0.75 | TP53 (0.33) | KMT2ATP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3966206-A1 | HETEROARYLAMINOPYRIMIDINE AMIDE AUTOPHAGY INHIBITORS AND METHODS OF USE THEREOF | Deciphera Pharmaceuticals, LLC (US) | 2022-03-16 | — | — | EP | claimed |
| EP-3966206-A1 | HETEROARYLAMINOPYRIMIDINE AMIDE AUTOPHAGY INHIBITORS AND METHODS OF USE THEREOF | Deciphera Pharmaceuticals, LLC (US) | 2022-03-16 | — | — | EP | disclosed |