Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.44 |
| ▸ | PPIB | P23284 | 1/20 | 0.42 |
| ▸ | S100A4 | P26447 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Spizofurone SCHEMBL933718 | 1.00 | KDM4E (0.46) | KDM4EHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL10334515 | 0.86 | HDAC3 (0.45) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL11386477 | 0.84 | PPIB (0.45) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL13182901 | 0.84 | ATM (0.54) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL11248254 | 0.81 | CYP1A2 (0.54) | KDM4EHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13158976 | 0.81 | HDAC3 (0.42) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL18157491 | 0.79 | S100A4 (0.46) | KDM4ES100A4NPC1RAB9AMAPT | |
| SCHEMBL11248793 | 0.77 | MAPT (0.53) | KDM4EHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL11379323 | 0.75 | HDAC3 (0.44) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL13481991 | 0.74 | MAPT (0.66) | KDM4ENPC1MAPTALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230190662-A1 | Efficacy of a Gastro-Retentive Bile Acid Sequestrant Dosage Form | IRONWOOD PHARMACEUTICALS, INC. | 2023-06-22 | — | — | US | disclosed |
| WO-2023080103-A1 | ADHESIVE PATCH WITH COVER MATERIAL | 久光製薬株式会社 | 2023-05-11 | — | — | WO | disclosed |
| US-20220370367-A1 | Gastro-Retentive Sustained-Release Oral Dosage Form of a Bile Acid Sequestrant | IRONWOOD PHARMACEUTICALS INC (US) | 2022-11-24 | — | — | US | disclosed |
| EP-3991719-A1 | GASTRO-RETENTIVE SUSTAINED-RELEASE ORAL DOSAGE FORM OF A BILE ACID SEQUESTRANT | Ironwood Pharmaceuticals, Inc. (US) | 2022-05-04 | — | — | EP | disclosed |
| US-20220110876-A1 | Gastro-Retentive Sustained-Release Oral Dosage Form of a Bile Acid Sequestrant | IRONWOOD PHARMACEUTICALS INC (US) | 2022-04-14 | — | — | US | disclosed |