Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | CTSA | P10619 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PTPRB | P23467 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27641754 | 0.84 | ALDH1A1 (0.42) | ALDH1A1PKMCTSANPC1RAB9A | |
| SCHEMBL27815004 | 0.79 | ALDH1A1 (0.43) | ALDH1A1PKMCTSANPC1RAB9A | |
| SCHEMBL29278491 | 0.78 | CTSA (0.40) | ALDH1A1CTSANPC1RAB9A | |
| Hydrochloric Acid SCHEMBL5247586 | 0.78 | ALDH1A1 (0.42) | ALDH1A1PKMCTSANPC1RAB9A | |
| SCHEMBL11188437 | 0.74 | ALDH1A1 (0.36) | ALDH1A1PKMCTSANPC1RAB9A | |
| SCHEMBL27339458 | 0.72 | TACR3 (0.39) | ALDH1A1PKMCTSANPC1RAB9A | |
| SCHEMBL28257842 | 0.71 | CTSA (0.45) | ALDH1A1CTSANPC1RAB9AL3MBTL1 | |
| SCHEMBL11275452 | 0.70 | LMNA (0.33) | ALDH1A1PKMCTSANPC1RAB9A | |
| SCHEMBL24328848 | 0.70 | CTSA (0.40) | ALDH1A1CTSA | |
| SCHEMBL8429804 | 0.70 | ALDH1A1 (0.51) | ALDH1A1PKMCTSANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139475-A2 | THE USE OF PDE7 INHIBITORS FOR THE TREATMENT OF MOVEMENT DISORDERS | Omeros Corporation (US) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008119057-A2 | THE USE OF PDE7 INHIBITORS FOR THE TREATMENT OF MOVEMENT DISORDERS | OMEROS CORPORATION (US) | 2008-10-02 | — | — | WO | disclosed |