Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XPO1 | O14980 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11997717 | 0.82 | KMT2A (0.50) | KMT2AKDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL31536297 | 0.82 | KMT2A (0.50) | KMT2AKDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9131695 | 0.78 | KDM4E (0.46) | KMT2AKDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13134390 | 0.77 | KDM4E (0.50) | KMT2AKDM4ERAB9ANPC1MAPT | |
| SCHEMBL7955683 | 0.77 | RAB9A (0.45) | KMT2AKDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL27904617 | 0.76 | GAA (0.54) | XPO1KMT2AKDM4ERAB9ANPC1 | |
| SCHEMBL10025629 | 0.72 | KMT2A (0.42) | XPO1ESR1HTR1APTGS1PTGS2 | |
| SCHEMBL1366867 | 0.72 | XPO1 (0.43) | XPO1ESR1HTR1APTGS1PTGS2 | |
| SCHEMBL30546146 | 0.71 | MAPT (0.52) | KMT2ASMN1; SMN2MAPTHTTALDH1A1 | |
| SCHEMBL26123781 | 0.71 | MAPT (0.52) | KMT2ASMN1; SMN2MAPTHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3802501-B1 | COMPOUNDS AS NUCLEAR TRANSPORT MODULATORS AND USES THEREOF | XWPHARMA LTD (KY) | 2024-02-28 | — | — | EP | claimed |
| EP-4461370-A2 | ANTIPROLIFERATIVE COMPOUNDS AND SECOND ACTIVE AGENTS FOR USE IN TREATING MULTIPLE MYELOMA | Celgene Corporation (US) | 2024-11-13 | — | — | EP | disclosed |
| EP-3908281-B9 | ANTIPROLIFERATIVE COMPOUNDS AND SECOND ACTIVE AGENTS FOR USE IN TREATING MULTIPLE MYELOMA | CELGENE CORP (US) | 2024-10-16 | — | — | EP | disclosed |
| EP-3908281-B1 | ANTIPROLIFERATIVE COMPOUNDS AND SECOND ACTIVE AGENTS FOR USE IN TREATING MULTIPLE MYELOMA | CELGENE CORP (US) | 2024-07-31 | — | — | EP | disclosed |
| CN-117229268-A | Hydrazide-containing nuclear transport modulators and uses thereof | 卡尔约药物治疗公司 | 2023-12-15 | — | — | CN | disclosed |
| CN-110372673-B | Hydrazide-containing nuclear transport modulators and uses thereof | 卡尔约药物治疗公司 | 2023-10-03 | — | — | CN | disclosed |
| CN-110372672-B | Hydrazide-containing nuclear transport modulators and uses thereof | 卡尔约药物治疗公司 | 2023-09-29 | — | — | CN | disclosed |
| CN-115315260-A | Therapy for treating cancer | 新基公司 | 2022-11-08 | — | — | CN | disclosed |
| EP-3962898-A1 | PROCESS FOR PREPARING XPO1 INHIBITORS AND INTERMEDIATES FOR USE IN THE PREPARATION OF XP01 INHIBITORS | Karyopharm Therapeutics, Inc. (US) | 2022-03-09 | — | — | EP | disclosed |