Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 2/20 | 0.37 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.37 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.37 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.37 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.37 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.37 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22617353 | 1.00 | KCNQ3 (0.37) | KCNQ3KCNQ2KCNE1KCNQ1KCNQ5 | |
| SCHEMBL22617462 | 0.89 | NR1H4 (0.38) | KCNQ3KCNQ2KCNE1KCNQ1KCNQ5 | |
| SCHEMBL29495497 | 0.83 | DPP8 (0.36) | KCNQ3KCNQ2KCNE1KCNQ1KCNQ5 | |
| SCHEMBL22617296 | 0.79 | HPGDS (0.55) | MLLT3MLLT1NR1H4NPC1MAPT | |
| SCHEMBL22617318 | 0.77 | GCGR (0.41) | HSD11B1 | |
| SCHEMBL27019009 | 0.77 | ATF4 (0.44) | MLLT3MLLT1NR1H4NPC1MAPT | |
| SCHEMBL29540588 | 0.76 | HPGDS (0.56) | EGLN1 | |
| SCHEMBL22617402 | 0.76 | HPGDS (0.56) | EGLN1 | |
| SCHEMBL24043473 | 0.75 | ATF4 (0.33) | NR1H4NPC1MAPTNFKB1RAB9A | |
| SCHEMBL22617387 | 0.75 | ATF4 (0.33) | NR1H4NPC1MAPTNFKB1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3962899-A1 | SUBSTITUTED CYCLOLAKYLS AS MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2022-03-09 | — | — | EP | disclosed |