Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | TLR8 | Q9NR97 | 15/20 | 0.48 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29496219 | 0.78 | PIK3CD (0.44) | MEN1KMT2ATLR8NCF1NOS2 | |
| SCHEMBL21223515 | 0.73 | KDM4E (0.49) | MEN1KMT2ATLR8NOS2KDM4E | |
| SCHEMBL1767757 | 0.72 | NPC1 (0.63) | NPC1RAB9AMEN1KMT2AATM | |
| SCHEMBL9129527 | 0.72 | ALDH1A1 (0.47) | NPC1RAB9AMEN1KMT2AATM | |
| Hydrochloric Acid SCHEMBL21223433 | 0.72 | KDM4E (0.48) | TLR8NOS2KDM4EALDH1A1 | |
| SCHEMBL17942849 | 0.72 | TLR8 (0.49) | NPC1RAB9AMEN1KMT2ATLR8 | |
| SCHEMBL1019128 | 0.72 | TLR8 (0.70) | NPC1RAB9AMEN1KMT2ATLR8 | |
| SCHEMBL29496028 | 0.71 | BACE1 (0.46) | NPC1RAB9AMEN1KMT2ATLR8 | |
| SCHEMBL29496272 | 0.71 | DAO (0.46) | RAB9AMEN1KMT2AATMKDM4E | |
| SCHEMBL22969237 | 0.70 | MCHR1 (0.49) | NCF1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4010328-A1 | 5-HETEROARYL-PYRIDIN-2-AMINE CONFOUNDS AS NEUROPEPTIDE FF RECEPTOR ANTAGONISTS | Domain Therapeutics (FR) | 2022-06-15 | — | — | EP | claimed |
| CN-114269730-A | 5-heteroaryl-pyridin-2-amine compounds as neuropeptide FF receptor antagonists | 多曼治疗学公司 | 2022-04-01 | — | — | CN | disclosed |