⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25410707 | 1.00 | — | — | |
| SCHEMBL30503568 | 0.81 | CHRM4 (0.32) | — | |
| SCHEMBL26631463 | 0.81 | CHRM4 (0.32) | — | |
| SCHEMBL29427075 | 0.79 | — | — | |
| SCHEMBL25410315 | 0.79 | — | — | |
| SCHEMBL29427106 | 0.77 | PDE4D (0.37) | — | |
| SCHEMBL25412820 | 0.77 | PDE4D (0.37) | — | |
| SCHEMBL29426927 | 0.76 | CHRM4 (0.34) | — | |
| SCHEMBL26750427 | 0.76 | CHRM2 (0.33) | — | |
| SCHEMBL26739485 | 0.76 | CHRM4 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240208902-A1 | CYCLOBUTYL AMIDE MONOACYLGLYCEROL LIPASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2024-06-27 | — | — | US | disclosed |
| US-11802111-B2 | Cyclobutyl amide monoacylglycerol lipase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2023-10-31 | — | — | US | disclosed |
| CN-116323557-A | Cyclobutylamide monoacylglycerol lipase modulators | 詹森药业有限公司 | 2023-06-23 | — | — | CN | disclosed |
| US-20220089538-A1 | CYCLOBUTYL AMIDE MONOACYLGLYCEROL LIPASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2022-03-24 | — | — | US | disclosed |