Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 1/20 | 0.34 |
| ▸ | DGKZ | Q13574 | 17/20 | 0.33 |
| ▸ | DGKA | P23743 | 5/20 | 0.32 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29499653 | 0.90 | DGKZ (0.36) | NQO1DGKZDGKASYK | |
| SCHEMBL29499643 | 0.71 | RPS6KA5 (0.39) | — | |
| SCHEMBL28556963 | 0.71 | NQO1 (0.41) | NQO1DGKZDGKA | |
| SCHEMBL30421173 | 0.68 | NQO1 (0.39) | NQO1DGKZDGKA | |
| SCHEMBL23529927 | 0.67 | NQO1 (0.40) | NQO1EGLN2 | |
| SCHEMBL29162219 | 0.67 | CA12 (0.43) | — | |
| SCHEMBL30791989 | 0.67 | NQO1 (0.40) | NQO1EGLN2 | |
| SCHEMBL30554391 | 0.67 | DGKZ (0.39) | NQO1DGKZDGKA | |
| SCHEMBL29499630 | 0.66 | MEN1 (0.41) | — | |
| SCHEMBL29911623 | 0.66 | LMNA (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114302884-B | Substituted pyridopyrimidinone compounds useful as T cell activators | 百时美施贵宝公司 | 2024-06-04 | — | — | CN | claimed |
| CN-114302884-A | Substituted pyridopyrimidinone based compounds useful as T cell activators | 百时美施贵宝公司 | 2022-04-08 | — | — | CN | claimed |
| CN-114302884-B | Substituted pyridopyrimidinone compounds useful as T cell activators | 百时美施贵宝公司 | 2024-06-04 | — | — | CN | disclosed |
| EP-4301755-A1 | COMBINATION OF A T CELL THERAPY AND A DGK INHIBITOR | Juno Therapeutics, Inc. (US) | 2024-01-10 | — | — | EP | disclosed |
| WO-2022187406-A1 | COMBINATION OF A T CELL THERAPY AND A DGK INHIBITOR | JUNO THERAPEUTICS, INC. (US) | 2022-09-09 | — | — | WO | disclosed |
| CN-114302884-A | Substituted pyridopyrimidinone based compounds useful as T cell activators | 百时美施贵宝公司 | 2022-04-08 | — | — | CN | disclosed |