Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 7/20 | 0.50 |
| ▸ | FEN1 | P39748 | 7/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | ERN1 | O75460 | 2/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23480395 | 0.85 | ALOX5AP (0.42) | ALOX5APFEN1ERN1TNKSTNKS2 | |
| SCHEMBL17236519 | 0.82 | PTPRC (0.51) | ALOX5APFEN1TRPA1ERN1TNKS | |
| SCHEMBL23347204 | 0.82 | ALOX5AP (0.56) | ALOX5APFEN1TRPA1PDE3BPDE3A | |
| SCHEMBL3689077 | 0.81 | ALOX5AP (0.46) | ALOX5APFEN1ERN1TNKSTNKS2 | |
| SCHEMBL3691088 | 0.77 | ERN1 (0.57) | ALOX5APFEN1ERN1TNKS2 | |
| SCHEMBL9287992 | 0.76 | ALOX5AP (0.50) | ALOX5APFEN1TRPA1PDE3BPDE3A | |
| SCHEMBL2948017 | 0.76 | ALOX5AP (0.54) | ALOX5APFEN1TRPA1PDE3BPDE3A | |
| SCHEMBL2480683 | 0.76 | ERN1 (0.41) | ABL1ERN1 | |
| SCHEMBL2946464 | 0.76 | ALOX5AP (0.41) | ALOX5APFEN1TRPA1PDE3BPDE3A | |
| SCHEMBL2946461 | 0.76 | ALOX5AP (0.41) | ALOX5APFEN1TRPA1PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396301-A2 | SMALL MOLECULE BRADYKININ B1 RECEPTOR ANTAGONISTS | Jerini AG (DE) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010091876-A2 | SMALL MOLECULE BRADYKININ B1 RECEPTOR ANTAGONISTS | JERINI AG (DE) | 2010-08-19 | — | — | WO | disclosed |