Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TNKS | O95271 | 1/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.46 |
| ▸ | CTSD | P07339 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23480395 | 0.88 | ALOX5AP (0.42) | ALOX5APFEN1TNKSTNKS2BACE1 | |
| SCHEMBL17236519 | 0.84 | PTPRC (0.51) | ALOX5APFEN1ALDH1A1TNKSTNKS2 | |
| SCHEMBL2950123 | 0.81 | ALOX5AP (0.50) | ALOX5APFEN1TNKSTNKS2ERN1 | |
| SCHEMBL2476180 | 0.80 | TNKS (0.46) | ALOX5APFEN1TSHRALDH1A1TNKS | |
| SCHEMBL5737521 | 0.80 | MCL1 (0.54) | TSHRALDH1A1CTSDBACE1LCK | |
| SCHEMBL28356802 | 0.80 | CTSD (0.49) | TSHRALDH1A1CTSDBACE1LCK | |
| SCHEMBL3691088 | 0.80 | ERN1 (0.57) | ALOX5APFEN1TSHRALDH1A1TNKS2 | |
| SCHEMBL3750014 | 0.78 | ALOX5AP (0.53) | ALOX5APFEN1TNKSTNKS2CTSD | |
| SCHEMBL5735316 | 0.78 | ALDH1A1 (0.51) | TSHRALDH1A1TNKS2ERN1 | |
| SCHEMBL12365168 | 0.77 | ALOX5AP (0.41) | ALOX5APFEN1TSHRALDH1A1TNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |