Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 7/20 | 0.50 |
| ▸ | FEN1 | P39748 | 7/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.42 |
| ▸ | PDE4A | P27815 | 3/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29501226 | 0.88 | DYRK1A (0.53) | ALOX5APFEN1PDE4BPDE4APDE4C | |
| SCHEMBL29501219 | 0.85 | ALOX5AP (0.47) | ALOX5APFEN1FFAR4PDE4BPDE4A | |
| SCHEMBL29501200 | 0.83 | PDE4B (0.46) | FFAR4PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL29501216 | 0.79 | TRPV4 (0.46) | ALOX5APFEN1PDE4BPDE4APDE4C | |
| SCHEMBL29501221 | 0.78 | FFAR4 (0.42) | ALOX5APFEN1FFAR4PDE4BPDE4A | |
| SCHEMBL16044623 | 0.78 | PDE10A (0.40) | FFAR4PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL29501234 | 0.76 | ALOX5AP (0.52) | ALOX5APFEN1FFAR4PDE4BPDE4A | |
| SCHEMBL29501208 | 0.74 | TRPV4 (0.43) | ALOX5APFEN1PDE4BPDE4APDE4C | |
| SCHEMBL16044370 | 0.74 | DHFR (0.46) | ALOX5APFEN1PDE4BPDE4APDE4C | |
| SCHEMBL29501224 | 0.74 | PDE10A (0.47) | ALOX5APFEN1NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250122172-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS PDE4 INHIBITORS | DART NEUROSCIENCE LLC | 2025-04-17 | — | — | US | disclosed |
| US-20230075774-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS PDE4 INHIBITORS | DART NEUROSCIENCE LLC (US) | 2023-03-09 | — | — | US | disclosed |
| US-11279691-B2 | Substituted pyridine and pyrazine compounds as PDE4 inhibitors | DART NEUROSCIENCE LLC (US) | 2022-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250122172-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS PDE4 INHIBITORS | PDE4A, PDE4B, PDE4D | ALOX5AP 3254/4885FEN1 4136/4885FFAR4 133/4885 |
| US-20230075774-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS PDE4 INHIBITORS | PDE4A, PDE4B, PDE4D | ALOX5AP 3254/4885FEN1 4136/4885FFAR4 133/4885 |
| US-11279691-B2 | Substituted pyridine and pyrazine compounds as PDE4 inhibitors | PDE4A, PDE4B, PDE4D | ALOX5AP 3204/4885FEN1 4105/4885FFAR4 133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.