SCHEMBL29501463

SCHEMBL29501463

Clc1cccc(Nc2cc(N3CCC(N4CCc5ccccc5C4)CC3)ncn2)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 2/20 0.53
CXCR3 P49682 1/20 0.43
CHRM4 P08173 4/20 0.41
EGFR P00533 2/20 0.41
CHRM2 P08172 1/20 0.41
CHRM5 P08912 1/20 0.41
CHRM1 P11229 1/20 0.41
CHRM3 P20309 1/20 0.41
NPC1 O15118 1/20 0.41
CASP3 P42574 1/20 0.41
RAB9A P51151 1/20 0.41
SENP8 Q96LD8 1/20 0.41
SENP7 Q9BQF6 1/20 0.41
SENP6 Q9GZR1 1/20 0.41
ERBB3 P21860 1/20 0.40
ADRA1A P35348 2/20 0.39
PRCP P42785 1/20 0.39
HRH4 Q9H3N8 1/20 0.39
TNNI3K Q59H18 1/20 0.38
PRMT5 O14744 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26248334 1.00 SCN9A (0.53) SCN9ACXCR3CHRM4EGFRCHRM2
SCHEMBL29501356 0.90 SCN9A (0.48) SCN9ACXCR3CHRM4EGFRCHRM2
SCHEMBL26248126 0.90 SCN9A (0.53) SCN9ACXCR3CHRM4CHRM2CHRM5
SCHEMBL29501415 0.89 SCN9A (0.53) SCN9ACXCR3CHRM4CHRM2CHRM5
SCHEMBL26248246 0.89 SCN9A (0.55) SCN9ACHRM4EGFRCHRM1ADRA1A
SCHEMBL29501369 0.88 SCN9A (0.52) SCN9ACXCR3CHRM4ADRA1AHRH4
SCHEMBL26248255 0.88 SCN9A (0.52) SCN9ACXCR3CHRM4ADRA1AHRH4
SCHEMBL26248568 0.87 SCN9A (0.52) SCN9ACHRM4ADRA1APRCPHRH4
SCHEMBL29501447 0.86 SCN9A (0.48) SCN9ACXCR3CHRM4CHRM2CHRM5
SCHEMBL26248714 0.86 SCN9A (0.48) SCN9ACXCR3CHRM4CHRM2CHRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022048631-A1 COMPOUND HAVING ANTITUMOR ACTIVITY AND USE THEREOF 上海翊石医药科技有限公司 2022-03-10 WO disclosed