Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 11/20 | 0.43 |
| ▸ | JAK3 | P52333 | 11/20 | 0.43 |
| ▸ | JAK1 | P23458 | 7/20 | 0.43 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23620391 | 1.00 | PRKDC (0.46) | PRKDCJAK2JAK3JAK1HCAR1 | |
| SCHEMBL20299431 | 1.00 | PRKDC (0.46) | PRKDCJAK2JAK3JAK1HCAR1 | |
| SCHEMBL25057364 | 1.00 | PRKDC (0.46) | PRKDCJAK2JAK3JAK1HCAR1 | |
| SCHEMBL23620418 | 0.86 | JAK2 (0.45) | PRKDCJAK2JAK3JAK1HCAR1 | |
| SCHEMBL1781369 | 0.85 | HCAR1 (0.48) | JAK2JAK3JAK1HCAR1TYK2 | |
| SCHEMBL23452644 | 0.85 | JAK2 (0.54) | PRKDCJAK2JAK3JAK1TYK2 | |
| SCHEMBL20329966 | 0.85 | JAK2 (0.54) | PRKDCJAK2JAK3JAK1TYK2 | |
| SCHEMBL29771039 | 0.85 | JAK2 (0.54) | PRKDCJAK2JAK3JAK1TYK2 | |
| SCHEMBL20359146 | 0.85 | JAK2 (0.54) | PRKDCJAK2JAK3JAK1TYK2 | |
| SCHEMBL1693604 | 0.84 | HCAR1 (0.50) | JAK2JAK3JAK1HCAR1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114315834-B | Imidazolone derivatives and their use in medicine | 成都百裕制药股份有限公司 | 2024-01-05 | — | — | CN | disclosed |
| CN-113121538-B | Furan derivative and application thereof in medicine | 成都百裕制药股份有限公司 | 2023-04-21 | — | — | CN | disclosed |
| CN-114315834-A | Imidazolidinone derivatives and their use in medicaments | 成都百裕制药股份有限公司 | 2022-04-12 | — | — | CN | disclosed |