Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21432292 | 1.00 | HDAC6 (0.50) | HDAC6KCNN3LMNAPDE10ASMN1; SMN2 | |
| SCHEMBL28406604 | 0.85 | HDAC6 (0.57) | HDAC6KCNN3SMN1; SMN2NPC1RAB9A | |
| SCHEMBL27898220 | 0.82 | RIPK1 (0.62) | HDAC6KCNN3LMNASMN1; SMN2NPC1 | |
| SCHEMBL3546237 | 0.81 | KCNN3 (0.57) | HDAC6KCNN3LMNASMN1; SMN2NPC1 | |
| SCHEMBL14155576 | 0.81 | RIPK1 (0.65) | HDAC6KCNN3LMNASMN1; SMN2NPC1 | |
| SCHEMBL7699200 | 0.79 | SMN1; SMN2 (0.51) | HDAC6KCNN3LMNAPDE10ASMN1; SMN2 | |
| SCHEMBL382481 | 0.79 | JAK1 (0.54) | HDAC6KCNN3SMN1; SMN2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL8130344 | 0.78 | JAK1 (0.53) | HDAC6KCNN3SMN1; SMN2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL5007369 | 0.78 | JAK1 (0.53) | HDAC6KCNN3SMN1; SMN2NPC1RAB9A | |
| Bromide SCHEMBL3874715 | 0.78 | JAK1 (0.53) | HDAC6KCNN3SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109071565-B | Tricyclic heterocyclic derivatives | 默克专利股份公司 | 2022-05-10 | — | — | CN | disclosed |