SCHEMBL2950419

SCHEMBL2950419

CCN(C(=O)OC(C)(C)C)c1ncc(-c2cc(Cl)cc(F)c2-c2cccs2)cc1F

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
BDKRB1 P46663 11/20 0.38
GBA1 P04062 1/20 0.37
GABRA1 P14867 1/20 0.35
GABRG2 P18507 1/20 0.35
GABRB3 P28472 1/20 0.35
GABRA5 P31644 1/20 0.35
GABRA3 P34903 1/20 0.35
GABRA2 P47869 1/20 0.35
GABRA6 Q16445 1/20 0.35
ACLY P53396 1/20 0.35
GRIN2B Q13224 2/20 0.35
HIF1A Q16665 1/20 0.34
HDAC1 Q13547 2/20 0.32
HDAC3 O15379 1/20 0.32
HDAC2 Q92769 1/20 0.32
ERN1 O75460 1/20 0.32
HDAC8 Q9BY41 1/20 0.32
HDAC6 Q9UBN7 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2950171 0.81 BDKRB1 (0.39) BDKRB1GRIN2BHIF1A
SCHEMBL2950422 0.77 HIF1A (0.41) BDKRB1GABRA1GABRG2GABRB3GABRA5
SCHEMBL2946726 0.71 BDKRB1 (0.42) BDKRB1GRIN2BHIF1A
SCHEMBL13213911 0.71 BDKRB1 (0.69) BDKRB1
SCHEMBL2946447 0.70 BDKRB1 (0.51) BDKRB1
SCHEMBL2951908 0.70 BDKRB1 (0.48) BDKRB1GRIN2B
SCHEMBL2946714 0.70 SSTR4 (0.37) HDAC1HDAC8HDAC6
SCHEMBL2940943 0.69 BDKRB1 (0.40) BDKRB1GRIN2B
SCHEMBL2950173 0.69 BDKRB1 (0.45) BDKRB1HIF1A
SCHEMBL2941734 0.69 HIF1A (0.35) BDKRB1GRIN2BHIF1AERN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2396301-A2 SMALL MOLECULE BRADYKININ B1 RECEPTOR ANTAGONISTS Jerini AG (DE) 2011-12-21 EP disclosed
WO-2010091876-A2 SMALL MOLECULE BRADYKININ B1 RECEPTOR ANTAGONISTS JERINI AG (DE) 2010-08-19 WO disclosed