Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.66 |
| ▸ | RAB9A | P51151 | 5/20 | 0.66 |
| ▸ | TP53 | P04637 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | IL2 | P60568 | 8/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | CASP3 | P42574 | 3/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.44 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2592609 | 1.00 | NPC1 (0.66) | NPC1RAB9ATP53SMN1; SMN2IL2 | |
| SCHEMBL2588687 | 0.93 | NPC1 (0.66) | NPC1RAB9ATP53SMN1; SMN2IL2 | |
| SCHEMBL15164958 | 0.87 | SMN1; SMN2 (0.57) | NPC1RAB9ATP53SMN1; SMN2HTT | |
| SCHEMBL1702038 | 0.84 | SMN1; SMN2 (0.52) | NPC1RAB9ATP53SMN1; SMN2IL2 | |
| SCHEMBL15164985 | 0.84 | NPC1 (0.55) | NPC1RAB9ATP53SMN1; SMN2IL2 | |
| SCHEMBL16323437 | 0.80 | IL2 (0.47) | NPC1RAB9ATP53SMN1; SMN2IL2 | |
| SCHEMBL15171293 | 0.79 | STIM1 (0.53) | NPC1RAB9ATP53SMN1; SMN2HTT | |
| SCHEMBL12155520 | 0.78 | L3MBTL1 (0.47) | NPC1RAB9ATP53SMN1; SMN2IL2 | |
| SCHEMBL17346806 | 0.78 | RAB9A (0.67) | NPC1RAB9ATP53SMN1; SMN2HTT | |
| SCHEMBL2582432 | 0.78 | SMO (0.54) | NPC1RAB9ATP53SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563759-B1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC (US) | 2022-04-06 | — | — | EP | disclosed |