Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.47 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 2/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.37 |
| ▸ | IP6K3 | Q96PC2 | 2/20 | 0.37 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1160196 | 1.00 | CYP2A6 (0.47) | CYP2A6P2RY14MAPTKDM4EALDH1A1 | |
| SCHEMBL1876553 | 0.85 | P2RY14 (0.48) | CYP2A6P2RY14MAPTKDM4EALDH1A1 | |
| SCHEMBL1418704 | 0.85 | HDAC1 (0.56) | CYP2A6P2RY14MAPTKDM4EALDH1A1 | |
| SCHEMBL8541511 | 0.83 | CYP2A6 (0.38) | CYP2A6P2RY14MAPTKDM4EALDH1A1 | |
| SCHEMBL4236815 | 0.81 | MAPT (0.42) | MAPTKDM4EALDH1A1APEX1RECQL | |
| SCHEMBL10465738 | 0.81 | MAPT (0.42) | MAPTKDM4EALDH1A1APEX1RECQL | |
| SCHEMBL4588444 | 0.81 | MAPT (0.42) | MAPTKDM4EALDH1A1APEX1RECQL | |
| SCHEMBL1874507 | 0.78 | P2RY14 (0.42) | CYP2A6P2RY14MAPTKDM4EALDH1A1 | |
| SCHEMBL3051314 | 0.77 | MAPT (0.41) | P2RY14MAPTKDM4EALDH1A1APEX1 | |
| SCHEMBL1880854 | 0.77 | TTR (0.54) | MAPTKDM4EALDH1A1TDP1MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313972-A1 | INDOLINE DERIVATIVES AS DDRS INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2024-02-07 | — | — | EP | disclosed |
| EP-4164638-A1 | REJUVENATION OF AGED TISSUES AND ORGANS BY INHIBITION OF THE PGE2 DEGRADING ENZYME, 15-PGDH | The Board of Trustees of the Leland Stanford Junior University (US) | 2023-04-19 | — | — | EP | disclosed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| WO-2022200577-A1 | INDOLINE DERIVATIVES AS DDRS INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2022-09-29 | — | — | WO | disclosed |
| CN-114668761-A | Novel ferroportin inhibitors | 威佛（国际）股份公司 | 2022-06-28 | — | — | CN | disclosed |
| CN-108290878-B | Novel ferroportin inhibitors | 威佛（国际）股份公司 | 2022-04-26 | — | — | CN | disclosed |