Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.34 |
| ▸ | IP6K3 | Q96PC2 | 2/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4236815 | 0.81 | MAPT (0.42) | MAPTKDM4ETDP1ALDH1A1APEX1 | |
| SCHEMBL10465738 | 0.81 | MAPT (0.42) | MAPTKDM4ETDP1ALDH1A1APEX1 | |
| SCHEMBL1160196 | 0.81 | CYP2A6 (0.47) | MAPTKDM4ETDP1ALDH1A1APEX1 | |
| SCHEMBL14051691 | 0.80 | HDAC1 (0.39) | MAPTKDM4ETDP1ALDH1A1APEX1 | |
| SCHEMBL13749268 | 0.78 | HDAC1 (0.40) | MAPTKDM4ETDP1ALDH1A1APEX1 | |
| SCHEMBL11436689 | 0.77 | HDAC1 (0.39) | MAPTKDM4ETDP1ALDH1A1APEX1 | |
| SCHEMBL2653187 | 0.77 | KDM4E (0.41) | MAPTKDM4ETDP1ALDH1A1APEX1 | |
| SCHEMBL2653189 | 0.77 | KDM4E (0.41) | MAPTKDM4ETDP1ALDH1A1APEX1 | |
| SCHEMBL10817399 | 0.77 | IP6K1 (0.59) | MAPTKDM4EALDH1A1HDAC1PKM | |
| SCHEMBL2606218 | 0.75 | HDAC1 (0.39) | MAPTKDM4ETDP1ALDH1A1APEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2748159-A1 | SERINE/THREONINE PAK1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-07-02 | — | — | EP | disclosed |
| WO-2013026914-A1 | SERINE/THREONINE PAK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-02-28 | — | — | WO | disclosed |
| US-7326720-B2 | Phenyl- and pyridylpiperidines with TNF activity | SANOFI-AVENTIS (FR) | 2008-02-05 | — | — | US | disclosed |
| US-7186720-B2 | Tetrahydropyridyl-alkyl-heterocycles, method for preparing the same and pharmaceutical compositions containing the same | SANOFI-AVENTIS (FR) | 2007-03-06 | — | — | US | disclosed |
| US-20040138264-A1 | Tetrahydropyridly-alkyl-heterocycles, method for preparing same and pharmaceutical compositions containing same | SANOFI-AVENTIS (FR) | 2004-07-15 | — | — | US | disclosed |
| US-20040127517-A1 | Phenyl-and pyridyl-piperidines with tnf activity | SANOFI-AVENTIS (FR) | 2004-07-01 | — | — | US | disclosed |
| US-6040449-A | USEFUL FOR FORMING FLUORINE CONTAINING 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES, USEFUL AS ANTAGONIST FOR MUSCARINIC M3 RECEPTORS AND LESS SIDE EFFECT | BANYU PHARMACEUTICAL CO LTD (JP) | 2000-03-21 | — | — | US | disclosed |
| US-5948792-A | POTENT AND SELECTIVE ANTAGONISTS FOR MUSCARINIC M.SUB.3 RECEPTORS WITH LITTLE SIDE EFFECTS. | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1999-09-07 | — | — | US | disclosed |
| EP-0930298-A1 | FLUORINATED 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1999-07-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127517-A1 | Phenyl-and pyridyl-piperidines with tnf activity | TNF, TNFRSF1A, NGFR | MAPT 3143/4885KDM4E 3255/4885TDP1 3456/4885 |
| US-20040138264-A1 | Tetrahydropyridly-alkyl-heterocycles, method for preparing same and pharmaceutical compositions containing same | CYP2F1, CYP11B1, CYP11B2 | MAPT 4119/4885KDM4E 2820/4885TDP1 2538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.