Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Carteolol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 8/20 | 0.98 |
| ▸ | ADRB1 known ✓ | P08588 | 8/20 | 0.98 |
| ▸ | ADRB3 known ✓ | P13945 | 2/20 | 0.61 |
| ▸ | HTR1A | P08908 | 4/20 | 0.98 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.98 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carteolol SCHEMBL41382 | 1.00 | ADRB2 (0.98) | ADRB2ADRB1HTR1AOPRK1ADRB3 | |
| Carteolol SCHEMBL41380 | 1.00 | ADRB2 (0.98) | ADRB2ADRB1HTR1AOPRK1ADRB3 | |
| Carteolol SCHEMBL30872857 | 0.99 | ADRB1 (1.00) | ADRB2ADRB1HTR1AOPRK1ADRB3 | |
| Carteolol SCHEMBL24810 | 0.99 | ADRB1 (1.00) | ADRB2ADRB1HTR1AOPRK1ADRB3 | |
| Carteolol SCHEMBL29908301 | 0.99 | ADRB1 (1.00) | ADRB2ADRB1HTR1AOPRK1ADRB3 | |
| Carteolol SCHEMBL24811 | 0.99 | ADRB1 (1.00) | ADRB2ADRB1HTR1AOPRK1ADRB3 | |
| Carteolol SCHEMBL146637 | 0.99 | ADRB1 (1.00) | ADRB2ADRB1HTR1AOPRK1ADRB3 | |
| Carteolol SCHEMBL2549082 | 0.99 | ADRB1 (1.00) | ADRB2ADRB1HTR1AOPRK1ADRB3 | |
| Carteolol SCHEMBL26664799 | 0.98 | ADRB1 (0.98) | ADRB2ADRB1HTR1AOPRK1ADRB3 | |
| Carteolol SCHEMBL26664802 | 0.98 | ADRB1 (0.98) | ADRB2ADRB1HTR1AOPRK1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114235998-B | Method for measuring related substances in carteolol hydrochloride and eye drops thereof by ultra-performance liquid chromatography | 山东省药学科学院 | 2022-10-25 | — | — | CN | disclosed |
| CN-114235998-A | Method for measuring related substances in carteolol hydrochloride and eye drops thereof by ultra-performance liquid chromatography | 山东省药学科学院 | 2022-03-25 | — | — | CN | disclosed |