Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | NR3C2 | P08235 | 9/20 | 0.49 |
| ▸ | PIK3C3 | Q8NEB9 | 5/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL501285 | 1.00 | L3MBTL1 (0.52) | L3MBTL1NR3C2PIK3C3JAK2JAK1 | |
| SCHEMBL91333 | 0.86 | RIOK2 (0.57) | L3MBTL1NR3C2PIK3C3JAK2JAK1 | |
| SCHEMBL7671508 | 0.86 | L3MBTL1 (0.52) | L3MBTL1NR3C2PIK3C3JAK2JAK1 | |
| SCHEMBL2642713 | 0.85 | L3MBTL1 (0.50) | L3MBTL1NR3C2PIK3C3JAK2JAK1 | |
| SCHEMBL21847287 | 0.85 | L3MBTL1 (0.50) | L3MBTL1NR3C2PIK3C3JAK2JAK1 | |
| SCHEMBL23015674 | 0.85 | NR3C2 (0.55) | L3MBTL1NR3C2PIK3C3MAPK14 | |
| SCHEMBL2642714 | 0.85 | LOXL2 (0.58) | L3MBTL1NR3C2PIK3C3JAK2JAK1 | |
| SCHEMBL4309482 | 0.85 | L3MBTL1 (0.50) | L3MBTL1NR3C2PIK3C3JAK2JAK1 | |
| SCHEMBL30893838 | 0.85 | L3MBTL1 (0.50) | L3MBTL1NR3C2PIK3C3JAK2JAK1 | |
| SCHEMBL5913167 | 0.84 | NR3C2 (0.53) | NR3C2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114341127-B | Aminopyrazine compounds as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2024-12-17 | — | — | CN | disclosed |
| CN-114341127-A | Aminopyrazine compounds as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2022-04-12 | — | — | CN | disclosed |