Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 4/20 | 0.49 |
| ▸ | CDK9 | P50750 | 4/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.49 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 11/20 | 0.41 |
| ▸ | JAK1 | P23458 | 9/20 | 0.40 |
| ▸ | JAK2 | O60674 | 5/20 | 0.40 |
| ▸ | TYK2 | P29597 | 5/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.40 |
| ▸ | CDC7 | O00311 | 2/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | PAK4 | O96013 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | PRKACA | P17612 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29508056 | 0.92 | CDK2 (0.49) | CDK2CDK9CCNT1CCNE2CCNE1 | |
| SCHEMBL29508122 | 0.91 | CDK2 (0.48) | CDK2CDK9CCNT1CCNE2CCNE1 | |
| SCHEMBL29538078 | 0.88 | CDK2 (0.50) | CDK2CDK9CCNT1CCNE2CCNE1 | |
| SCHEMBL26619221 | 0.88 | CCNE2 (0.48) | CDK2CDK9CCNT1CCNE2CCNE1 | |
| SCHEMBL29537557 | 0.88 | CCNE2 (0.48) | CDK2CDK9CCNT1CCNE2CCNE1 | |
| SCHEMBL29508053 | 0.87 | CDK2 (0.49) | CDK2CDK9CCNT1CCNE2CCNE1 | |
| SCHEMBL29507910 | 0.86 | CDK2 (0.44) | CDK2CDK9CCNT1CCNE2CCNE1 | |
| SCHEMBL29537792 | 0.85 | CCNT1 (0.50) | CDK2CDK9CCNT1CCNE2CCNE1 | |
| SCHEMBL29250640 | 0.85 | CCNT1 (0.50) | CDK2CDK9CCNT1CCNE2CCNE1 | |
| SCHEMBL29508070 | 0.85 | CDK2 (0.43) | CDK2CDK9CCNT1CCNE2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4237088-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | Blueprint Medicines Corporation (US) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022094355-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | LENGO THERAPEUTICS, INC. (US) | 2022-05-05 | — | — | WO | disclosed |