Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.58 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3826882 | 1.00 | HPGD (0.58) | HPGDHSD11B1HSP90AA1USP2POLB | |
| SCHEMBL3426843 | 0.98 | HPGD (0.55) | HPGDHSD11B1HSP90AA1USP2POLB | |
| SCHEMBL22767344 | 0.87 | HPGD (0.58) | HPGDHSD11B1HSP90AA1USP2POLB | |
| SCHEMBL22405367 | 0.86 | P2RX7 (0.45) | HPGDHSD11B1USP2POLBTSHR | |
| SCHEMBL22767193 | 0.85 | HPGD (0.55) | HPGDHSD11B1HSP90AA1USP2POLB | |
| SCHEMBL20750320 | 0.84 | RXFP1 (0.63) | HSP90AA1NPC1 | |
| SCHEMBL34473520 | 0.84 | RXFP1 (0.63) | HSP90AA1NPC1 | |
| SCHEMBL4766465 | 0.84 | MAPT (0.61) | HPGDHSP90AA1TSHRNPC1CA12 | |
| SCHEMBL30309430 | 0.84 | LMNA (0.60) | HSP90AA1POLBTSHRKMT2AMEN1 | |
| SCHEMBL2522286 | 0.84 | LMNA (0.60) | HSP90AA1POLBTSHRKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767674-B2 | Kinase inhibitors | ELI LILLY AND COMPANY (US) | 2010-08-03 | — | — | US | disclosed |
| EP-1960371-B1 | QUINAZOLEINE DERIVATIVES USED AS INHIBITORS OF ERBB TYROSINE KINASE | ASTRAZENECA AB (SE) | 2009-09-16 | — | — | EP | disclosed |
| US-20090029968-A1 | QUINAZOLINE DERIVATIVES USED AS INHIBITORS OF ERBB TYROSINE KINASE | ASTRAZENECA AB (SE) | 2009-01-29 | — | — | US | disclosed |
| US-20080306068-A1 | Suppression cytokines, tumor necrosis factor | ELI LILLY AND COMPANY (US) | 2008-12-11 | — | — | US | disclosed |
| EP-1960371-A1 | QUINAZOLEINE DERIVATIVES USED AS INHIBITORS OF ERBB TYROSINE KINASE | AstraZeneca AB (SE) | 2008-08-27 | — | — | EP | disclosed |
| US-7241769-B2 | Pyrimidines as PLK inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-07-10 | — | — | US | disclosed |
| US-7241769-B2 | Pyrimidines as PLK inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-07-10 | — | — | US | disclosed |
| WO-2007063293-A1 | QUINAZOLEINE DERIVATIVES USED AS INHIBITORS OF ERBB TYROSINE KINASE | ASTRAZENECA AB (SE) | 2007-06-07 | — | — | WO | disclosed |
| CN-1829704-A | Benzo [1,2,5] thiadiazole compounds as CCK2 modulators | JANSSEN PHARMACEUTICA NV (BE) | 2006-09-06 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306068-A1 | Suppression cytokines, tumor necrosis factor | TNF, TNFRSF1A, IL2 | HPGD 891/4885HSD11B1 969/4885HSP90AA1 807/4885 |
| US-20090029968-A1 | QUINAZOLINE DERIVATIVES USED AS INHIBITORS OF ERBB TYROSINE KINASE | ERBB2, ABL1, ERBB3 | HPGD 985/4885HSD11B1 4373/4885HSP90AA1 484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.